OPTRACT

Optimal Polymer encapsulated Tissue transport for Regenerative Applications, Cell therapy and Transplant

 

Regenerative medicine applications fundamentally use cells and cell secreted products to restore, regenerate, repair, lost or dysfunctional or damaged cells, tissues and organs. 

Cells whether they are from autologous or allogenic sources, when derived from tissue/organ of human origin, those tissues when harvested from the patient/subject have to be brought to a laboratory for processing and for this, the maintenance of integrity of the tissues at appropriate temperature become vital, enable the cells to become optimal source of regenerative therapies, with good viability and products with functional capability for suitable clinical applications.

We have the NCRM-GNC-JBM team working on the transportation of several cells, tissues using a novel polymer based methodology such as:


1.  The cornea for deriving corneal limbal stem cells and corneal endothelial precursor cells. Ref. Biotechnology Letters 2021. doi:10.1007/s10529-021-03116-y; Indian J Ophthalmol. 2014 Feb; 62(2): 130–135. doi: 10.4103/0301-4738.116457 and Tissue Eng Part A. 2009 Feb;15(2):407-15.doi: 10.1089/ten.tea.2008.0041


2. Cartilage Tissue for deriving chondrocytes – Enriched with Essentials and Lapped in Scaffold Transplant- suitable Autologous Leveraged Chondrocytes (EELS-TALC)


3.  Buccal Epithelial Tissue for use in urethral stricture repair – Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS)


Having proven that the above tissues can be satisfactorily transported using the OPTRACT methodology, we are also undertaking research on transportation of other types of cells, tissue and in the future this method could be of help for organ transport as well.