Research in Multiple Sclerosis
Multiple Sclerosis is a debilitating neurological illness, which occurs due to the damage to myelin sheath that covers the nerves, that are critical for their function. The exact cause is not clearly known and also no definitive remedies to cure the illness available at the moment. As we found the need for a safe, adverse reaction free, immune modulating agent with potentials to control the immune reaction that causes damage to the myelin sheath, we undertook a clinical study using N-163 strain of Aureobasidium Pullulans produced beta 1,3-1,6 glucans, based on the earlier evidence as anti-inflammatory adjuvants in pre-clinical and clinical studies in other illnesses with immune-hyperactivation. The clinical study yielded both clinical improvements in terms of EDSS score and also beneficial reconstitution of gut microbiome in the affected patients.
Our findings gain significant importance, because currently the correlation of abundance of specific gut microbiota with severity and progress of the complex pathogenesis of Multiple Sclerosis is the only clue, we have in our efforts to find a remedy.